Apigenin reddit. Has anyone else? If I recall the half life is four days.

Apigenin reddit When I take it in the evening however, I get really vivid and uncomfortable dreams. Parsley is by far the best source of Apigenin in terms of %, so use that in your food dishes or get a parsley supplement. I wake up feeling like I had an amazing night sleep- deep. I only take 50mg per night. Wonder if this is providing deeper sleep. similar Apigenin will not absorb on its own unless its from a food source. (Was actually going to stop taking any NMN for a couple of weeks to see if my sleep improves. Published reviews all focused on the findings using eukaryotic cells, animal models, or epidemiological studies covering the pharmacokinetics, cancer chemoprevention, and drug interactions of apigenin; however, no review is available on the antimicrobial effects of apigenin. Chamomile is on average only 0. 2% apigenin by weight Half-life of 91. I definitely think chamomile/apigenin helps, as does the magnesium (and magnesium is a pretty important mineral to supplement with anyway so it's worth having, sleep aside). , 2016), this would equate to a daily dose of approximately 40mg apigenin, less than 1% of what is needed for a meaningful clinical outcome on cancer cell behavior, although it may have other beneficial effects on health. I heard from Hubermans podcast that women shouldn’t take it, because it lowers estrogen but wouldn’t lowering estrogen levels also be bad for men? Hello everybody. I saw Huberman recommended Apigenin, from Chamomile, on a recent JRE. It did improve my sleep, however, it also seems to mess with many other things, at Baical Skullcap contains apigenin, at about 15%. I've started taking apigenin (200mg ND) alongside tongkat (2% ND) to mitigate the risk of any prolactin from the tongkat, as per what was discussed on the ND podcast a while back. Hey everyone so I started using apigenin 250mg nightly but it's been weird. 8hrs. I'm trying this after trying chamomile and lemon balm, which contain apigenin and r/Apigenin: A community for recreational use of apigenin, a flavonoid that acts on on BZD and GABA receptors. Consuming several spoonfuls (or more, depending on source of apigenin amounts) of parsley a day is inconvenient, as well as storing hundreds of grams of parsley at a time in giant containers. They intraperitoneally injected the apigenin to the mice. It’s great stuff. I purchased the 200mg Apigenin after hearing somewhere that it was great for sleep. 8 to 1. at least that's how I took it, not too familiar with what cell monolayers are though. One gram before bed is an absolutely perfect dose. It did improve my sleep, however, it also seems to mess with many other things, at Took 200mg Apigenin + 300mg ND Bacopa extract a few hours ago -- more sleepy than I normally would be right now with just the bacopa. Apigenin has some good effects to help anxiety and insomnia. On one hand it lowers dht then on the other hand Lab studies suggest that apigenin plays a role in testosterone synthesis and blocks signaling of testosterone repressing proteins. One time I took 100 and it knocked me out but I felt more groggy the next morning. So I'm thinking of trying high amounts of dried parsley to get high amounts of apigenin (aimed at gym performance). I am using NMN and NR sublingually. For psychosis-related anxiety, there is chamomile (apigenin), magnolia bark (magnolol), valerian root, ashwagandha, passionflower, tea made from the flower petals of leonotis leonorus var. I've taken apigenin off and on the last couple years, it's fantastic for sleep and anxiety, as long as you're cautious about the absurd 90 hour half life. Please note: Content on r/MCAS is not medical advice and should not be interpreted as such. For experiences and discussions related to quitting phenibut. Advertise on Reddit; Shop Collectible Avatars; Magtein and apigenin consistently boost my REM and deep sleep. In theory that would cause stimulation and convulsant effects however studies show that Apigenin can cause sedative effects. L-tyrosine over all of them. Rauschert) teas from different countries, published in the Journal of Chamomile Research (vol. Apigenin, which is found abundantly in chamomile tea is shown to drastically reduce cortisol (the main stress hormone elevated by caffeine) by as much as 47% with exponential efficacy (essentially, the more tea the better) It's a about chamomile which contains apigenin but they do not say that the prolactin lowering effects of chamomile is due to apigenin. Our previous research has found the antiadipogenic effects of apigenin on HepG2 cells. Medical uses or supplementing use is Apigenin seems to be great to helping sleep and NAD+ increase. Apigenin or Phosphatidylserine For the last 3 night I've been micro dosing melatonin ( . I recently purchased Apigenin for all its said benefits, but particularly to help with sleep. A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any Has anyone has bloodwork done post Apigenin? I have been trying to raise my E2 slightly, but have also had great success with Apigenin in the past in that it aids my sleep. The label says: Apigenin (from grapefruit) 50mg. But anyway I don’t know what it is, I take it after food in the early afternoon and I feel amazing! Started taking magnesium threonate and apigenin after listening to the HubermanLab podcast. These effects, combined with the GABAergic effects of baicalin, baicalein and apigenin is likely what causes the interesting calming yet non-lethargy inducing effects that are not stimulating yet do seem to enhance focus. I wouldn't buy from that brand for Apigenin, bought their Rhodiola years ago and they did the "review the Apigenin is also recovered at basal levels up to 10 days post ingestion, indicating slow excretion kinetics due to slow decomposition in the liver. Found this thread after searching for dreams and apigenin. Wondering if I noticed this also, I've been taking for few weeks and the last two days damn, she was even impressed lol, I struggle with some issues and the L-pyroglutamic acid really helped. Apigenin, as a natural flavonoid, has been proved to have many biological effects. But feel groggy in the AM- it’s like the feeling u get when u sleep too much. Apigenin is found to inhibit the inducible NO synthase and cyclooxygenase-2, which are enzymes parttaking in the inflamatory pathway. I still wake up early after like 6 hours tho and then have to fall back asleep again, so that part of the problem still remains. I’m in Ontario so I was wondering if anyone has purchased any from a health food store here? I keep seeing it sold as liposomal, but I am wondering if it is necessary? Just purchased some 50mg Apigenin from nootropics depotthanks! Get app Get the Reddit app Log In Log in to Reddit. I'd say it took a good 48h to feel my normal baseline I have taken apigenin on and off for sleep and chemoprevention of cancer I see that Life Extension uses it in their Senolytic Activator formula. if anything, creatine, green tea can boost dht. View community ranking In the Top 5% of largest communities on Reddit. However now I’m waking up after just 4-5 hours and can’t get back to sleep. One gram before bed is an absolutely perfect I drink chamomile tea but you don't get a lot of apigenin in it What side effects have people experienced? jump to content. 's study on the content of essential oil, terpenoids, and polyphenols in commercial chamomile (Chamomilla recutita L. not Thanks, I've been looking into apigenin today and will add it to my ADHD, depression and anxiety stack: Saffron ALCAR Black seed oil L-Citrulline I had to give up Magnesium as all forms as were making me worse. I take apigenin also but yeah I noticed no difference with the apigenin. This subreddit is dedicated to men on testosterone replacement with a goal of providing an engaging and cooperative environment to Abstract. When I do not take, those metrics suffer. I've read somewhere that it may function as an SSRE, similar to the original proposed MoA of Tianeptine. Easier to get and keep erections. " (The quote is from this article summary. even coffee. First of all I’m honored you responded to me, ima big fan. Blocks all three opioid receptors incredibly mildly It is general opioid. Btw if you do take TA later it’s helpful to take Apigenin as it will keep prolactin levels in check. 3mg 6hr time released) taken when it gets dark outside. I am on L-theanine but it doesn't do much for me. any feedback would be Where can I purchase apigenin in Canada? I see I can purchase it on Amazon but the price for shipping is just as much as the bottle. Because of its potential impact on hormone levels, it has become more popular to use apigenin for bodybuilding efforts. Could just be that I ate too many pistachios, tho 🤣 Will keep doing this daily and will add updated (minus the pistachios) So how did that go , go ,? All I've seen here is non smokers downplaying people who want to experiment the combustive properties of parsley and chamomile , for heavy tobacco users it also may be a life line as an experiment mechanism to taper down their tobacco use and science has proven that apigenin has effects that counter the dental plaque negative effects of tobacco 348K subscribers in the Supplements community. true. I know the Huberman stack lists it as 50mg taken 30 minutes before bed, but it seems like a lot of people also take it in the morning. I skipped a few days of taking the apigenin, only taking the other two, and I feel my sleep has been worse. However, after taking the apigenin around 7pm the night before, I was incredibly groggy for the whole next day. sex drive was already pretty healthy but it’s almost a problem like I am horny like a teenager all day , over all less lethargic and more apt to engage in conversations and my words just seem to flow a bit better recently I will definitely cycle off apigenin after this batch and note 16 votes, 14 comments. The literature suggests it is an aromatase inhibitor and so these two goals may not go hand in hand - how powerful is it in this action? There’s studies showing it can help lower body temperature which is helpful/ necessary for sleep. Reply reply Those glycoside conjugates, primarily as apigenin-7-O-glucoside, and acylated derivatives are more water soluble than apigenin [10] and their structures have a major impact on their absorption and bioavailability, with the best bioavailability occurring Apigenin popped up in my head since it's used as a sleep aid so it must have some anti-anxiety properties. As others have noticed one day isn’t useful. 14 votes, 14 comments. For example, there is some evidence that lipo apigenin is 450 percent or so more bioavailable than non-lipo apigenin. I acquired a third-party tested 98% pure powder of Apigenin. Apigenin So I started taking 200mg pigenin to help lower prolactin from the Cistanche I take at night and possibly adding Tongkat Ali 2%, not sure yet if I’m going to do that. This post is in regards to the dosage timing of Apigenin. Ive been taking apigenin for around 6 months at doses of 200-600mg a day. The dose What Do Personal Experiences and Reddit Discussions Reveal About Apigenin? Online community discussions highlight consistent reports of improved sleep quality and reduced anxiety with apigenin supplementation. Some people have also said the 200mg dose that ND recommends can be stimulating. Apigenin is a flavonoid of low toxicity and multiple beneficial bioactivities. Log In / Sign Up; Advertise on Reddit; Shop Collectible Avatars; So I ordered some apigenin supplements. gov/27449921/ Found this thread and wanted to comment a year later just to say that this Apigenin stuff is pretty whack. Chamomile tea is a good source, but it only contains a few % Apigenin. An average bag has maybe 300 mgs of flower in it. From a timing context, i take the lipitor right after dinner w coq10, and the apigenin would be around 10ish. In this study they compared chamomile to Cabergoline. A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. I think the Apigenin is also a key part. I was unable to take Apigenin the first 10-14 days and noticed large improvement when able to take all 3 consistently. I’ve tried this stack quite a few times but Huberman’s initial recommendations were 300-400mg of threonate and at least 200mg of l-theanine. From the nootropics depot podcast, they recommended apigenin to lower prolactin to prevent gyno and other side effects from Apigenin is the active ingredient in chamomile tea that makes you sleepy. Get app Get the Reddit app Log In Log in to Reddit. Using an apigenin content for dried parsley of 45mg/g (Sung et al. Sort by: Best. 5), the data most widely used online. I currently already take apigenin but read something about its effect on blocking estrogen so I wasn’t sure if it would be safe to take alongside the others. Terms & Policies Apigenin appears to be a mild dopamine D2 agonist and baicalin appears to enhances dopamine synthesis + release. Though you all would be interested to know! I had 4 chamomile tea yesterday and have had 2 today. Is this a decent stack for lifting and mood improvement? Apigenin is what we are using to activate the Yamanaka Factor genes, as opposed to using Forskolin and RepSox, which is what they used in the resource at the top. But I read it's also a 5-ar inhibitor - wondering if the DHT decrease would be substantial at around 50 mg I grabbed some dried organic parsley a couple weeks ago to try out (parsley has the highest apigenin content of any dried herb). That may not be enough parsley to get apigenin works on the same receptors as benzodiazepines. Assuming that in 100g of dried parsley there are 4503. So you'd need like 8 grams of chamomile to even reach the amount of apigenin in a 100mg apigenin supplement. I guess I use apigenin when I need it one of those nights or at least until my circadian rhythm becomes solid. Could this be a side effect of raising my testosterone / lowering estrogen? Does Apigenin lower blood pressure enough that if you take anything else with blood pressure lowering effects it could be a problem? I've taken Turmeric along with Citrulline before and had bad results from too low of BP in a workout, so I'm curious if Apigenin falls into this bucket so I should be more careful with my timing. I've used some form of apigenin for 3-4 years, and mostly liposomal variants for the last year. ) I take so many supplements, that I'd like to eliminate the Apigenin if the TMG is in its place. With apigenin, I remember them well after I wake up, almost like when I It's not just Kappa, it's an antagonist at all opioid receptors. Maybe I would avoid injecting 800mg of apigenin into your abdomen. edit subscriptions. For me if I take Theanine before bed it keeps me awake, if I take it 5 hours before it helps me fall asleep faster and I sleep deeper. Anyone take apigenin? I bought it after watching his sleep podcast and the first time I took it I felt like it took a long while to actually fall asleep. Assuming dried parsley contains an average of 113mg per gram you would need to buy roughly 40 dried grams of dried parsely to get the same amount of apigenin in one 90 capsule Swanson bottle (4500mg). , and its metabolites (SCFAs), attenuating DSS-induced colon injury. In a work/motivation sense this trumps tryptophan (less bioavailable version of 5HTP) which, increases your serotonin. 5% of control group I just got some of the apigenin powder and I’m looking to try it out primarily as a sleep aid. Magnesium Threonate 300-400 mg (Go expensive) Apigenin 50 mg (Camomile Derivative) L-Theanine 100-400 mg, 200 mg (intensifies dreams) Bisglycinate does work a lot better than threonate for me, but I still have sleep issues on the stack. 2 mg in 200 ml of chamomile tea. they also say pycnogenol decreases dht which is funny because they don't say in what amount and high dose pycnogenol paired with arginine is the cure for 90% cases of ED in few months. I dream most nights but they are hazy. All three are not very bioavailable, but taking the liposomal forms make them more so. /r/tall: reddit from a higher perspective. Is there any study saying apigenin is unsuitable or not helped by liposomal delivery? I know anecdotes are of very low value, but as far as supplements go, liposomal apigenin is the single supplement that has given me (40+m) the most noticeable quality of life improvement (significantly more restful sleep) of the group I take (NMN and some others). I enjoy apigenin on its own but cannot have lemon balm before bed with it now. Started off smooth with some benefits, however my sleep has been getting worse and worse, and I'm noticing that initial cortisol surge getting less and less in the morning (more fatigue in general). It says each capsule is 50mg but when I look up chammoile tea is says it A study in Brain published this week showed that "mice treated with either apigenin or sulphaquinoxaline cleared amyloid beta significantly faster than those treated with either of the two inactive substances. forbes upvotes Get app Get the Reddit app Log In Log in to Reddit. I have also in the past used double woods apigenin, 50 mg per capsule, for around 6 dollars a month. But to give you a sneak peek of what we discuss, Apigenin is effective at managing prolactin levels, Apigenin GABAA α1 benzo agonist, antiadrenergic. so is apigenin just a lighter form of benzos, that occurs natural, but is not better per se just because its not synthetic? i would like to drink chamomille tea for anxiety and sleep but i frequently have adverse effects, rebounds and stuff to substances, so not sure if a good idea, i think i could have some nasty withdrawal even I've tried various combinations of magnesium glycinate, l-theanine, and chamomile extract (couldn't find apigenin). Share Add a Comment. I cannot recall the specific citation for that though. 11K subscribers in the quittingphenibut community. However I’m not sure I’ve stumbled on convincing evidence that apigenin helps sleep. If anything I slept slightly better. Has anyone tried apigenin for sleep? I have heard the Tim Ferris podclip with Dr. From products to procedures, nothing is off limits and you'll be able to share information with like minded people. But it also competitively binds to the benzodiazepine site which may attribute to the sedation. Or check it out in the app stores Has someone tried Apigenin? Full spectrum Swanson products are not extracts. 2 months ago I started taking Apigenin on top of my stack of magnesium and l-theanine. I haven't felt much of a strong affect from it benefits or side affect wise. It makes it a lot easier for me to sleep, and Those glycoside conjugates, primarily as apigenin-7-O-glucoside, and acylated derivatives are more water soluble than apigenin [10] and their structures have a major impact on their absorption and bioavailability, with the best bioavailability occurring In my opinion, this is one of the most potent anxiolytics when it comes to quelling caffeine-induced anxiety and withdrawal symptoms. Apigenin is a bioactive flavone found in many plants, particularly known for its calming effect upon the nervous system I've taken apigenin off and on the last couple years, it's fantastic for sleep and anxiety, as long as you're cautious about the absurd 90 hour half life. I’ve just ordered Tongkat 10%, B-Ecdysterone, Caffeine+L-Theanine, and Apigenin. ). However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are allowed as responses to this comment. Those glycoside conjugates, primarily as apigenin-7-O-glucoside, and acylated derivatives are more water soluble than apigenin [10] and their structures have a major impact on their absorption and bioavailability, with the best I’ve just ordered Tongkat 10%, B-Ecdysterone, Caffeine+L-Theanine, and Apigenin. I'm excited you'll soon be offering Liposomal Apigenin, as this flavonoid is otherwise not very bioavailable. Apigenin increased ZO-1, claudin-1 and occludin expressions to restore the integrity of the intestinal barrier. I never seen much about Apigenin in context to playing better in competitive. I’ve tried Baicalin, baicalein and apigenin and I’ve tried creating my own ratios, but ND really nailed it on the head. I'm in bed a couple hours later. Hi ND and ND Reddit, I just ordered some polygala and some Apigenin 200mg. Between it’s anxiolytic effects and it’s muscular hypertrophic effects, I would be quite interested in purchasing this. 2% apigenin. New comments cannot be posted and votes cannot be cast. I researched that Apigenin, a flavonoid in chamomile, is a central Benzodiazepine Receptor Agonist at GABA Type A receptor. Apigenin has become one of my favorite supplements it's improved my mood, reduced anxiety, improved my sleep, acts as an AI, and it has been shown to increase your ability to build muscle and reduce the amount lost as you age. Apigenin popped up in my head since it's used as a sleep aid so it must have some anti-anxiety properties. https://pubmed. It's quite a remarkable Flavonoid! But since taking apigenin 50mg daily at night to help with sleep ive noticed HUGE change in libido, im chasing sex again, and instead of taking 40-60ish mins to climax, its happening incredibly fast, to the point i think i need to take it less often. Upon further research, it affects GABA-A, but may also have some MAOI effect. . I think that apigenin for the first two weeks was the most potent supplement I had taken in a long time. r/AusSkincare is a place for all Australian and New Zealand Reddit users (and anyone else, really!) to come and discuss all things skincare related. I Can spend days awake in a lucid dream from apigenin and then come back to Earth and it’s been 5hrs. Hello, I was wondering if ND would ever stock a high concentration chamomile extract, with a standardized apigenin concentration. Anecdotal for sure, but so far the apigenin is doing nothing for me. This could be causing it to have more stimulating effects from more absorbing. Please read the FAQ and Rules sections before posting. Chamomile, regarding apigenin which seems to be the most relevant component, it is not clear to me whether or not it can increase DHT, r/AusSkincare is a place for all Australian and New Zealand Reddit users (and anyone else, really!) to come and discuss all things skincare related. 636), the concentration of apigenin is reported to be around 4. This is a natural precursor to dopamine = the reward neurotransmitter in the brain. Moreover, apigenin remodeled the disordered gut microbiota by regulating the abundance of Akkermansia , Turicibacter , Klebsiella , Romboutsia , etc. Not a place for discussion of illicit and illegal compounds. I know that camomile has long been believed to help sleep and that camomile contains apigenin. I only seen two comments in a post saying that it is really good. 4, 2022, p. Tracked how my sleep quality changed during that time I took the supplements try search for it on reddit you will find lots of anecdotes. nlm. Instead of threonate try glycinate, 2g glycinate (~280 mg elemental magnesium, 60% rdv), 200mg theanine work for most (on empty stomach) and id suggest taking dry parsley, not a supplement for apigenin, 3g of dry parsley contain 140 mg apigenin, an decent apigenin dose. So I’m wondering if I take the Apigenin way earlier in the day, would I still get the benefits pertaining to sleep? Any info is appreciated. Thus the neuroprotective effect of Damiana. For a long while, I was passing out and waking up after 7-8 hours with so much energy. If I go to sleep by 10pm would I be fine to take this around 6pm? Another stilbenoid that can work synergistically with resveratrol is pterostilbene. It's not an acute effect, but for me it only took about 4 days for it to really kick in. Apigenin actually took me from withdrawals to feeling really good, not jut out of withdrawal. My sleep numbers on my Oura ring have never been this high. 11 votes, 19 comments. apigenin It's weird one. This study shows that it increases the bioavailability of rosmarinic acid which is what's in lemon balm. I do feel like I have had 5mg of Valium right now. Perfect timing! u/pretty-chill and I discuss prolactin lowering supplements in a new episode of our monthly podcast, In Search of Insight, which we're releasing tomorrow. Is this a decent stack for lifting and mood improvement? Welcome to r/TRThelp! We are a higher-quality community for men on testosterone. Cheers. Been trying to add apigenin to my stack to see if it solves the problem, but unfortunately it's out of stock. I have noticed no impact on sleep. MYASD actually did respond recently about this: I have been taking apigenin for about a week and noticed nothing. Log In / Sign Up; Advertise on Reddit; Shop Collectible Avatars; I do notice after waking up I tend to be irritable and short tempered from apigenin and cistanche. But as an older person, I have experienced great benefit from taking the Liposomal Apigenin in the evening with better sleep, particularly deep sleep. If the ratings were based on volume of the substance, I would expect lycopene to be a very good inhibitor, because tomato products and watermelon are so easy to get in the diet in quantity. If you scale their mouse doses to humans, that toxicity started around 800mg for a 75kg (165lbs) person. I consume 15 mg of lipo apigenin in a combo product at lunch and 35 mg of lipo apigenin in a standalone product after dinner. Last night I For a while I felt like my sleep was not very restful so I tracked it for two weeks then decided to take Apigenin. Cabergoline was definitely stronger but chamomile also had a significant effect "Apigenin is a flavone under the category of natural flavonoid that is abundantly present in common fruits, vegetables, nuts, onions, oranges, and tea" from ScienceDirect. Log In / Sign Up; Advertise on Reddit; Shop Collectible Avatars; Get the Reddit app Scan this QR code to download the app now. (I take a small 50 mg dose of Liposomal Code Age Apigenin after reading Dr. I ran out of the apigenin and magnolol/honokiol about a week ago and have kept up the 3g glycine and 5g l-glutamine with 2g NAC every night only and been sleeping really good with zero withdrawal during the day. Dried parsley only has more apigenin relative to its mass because the water is drained out. my subreddits. I see a lot of anecdotal statements about a stimulating experience initially upon taking this higher dosage. These remarkable pharmacokinetics warrant further studies in human subjects to ascertain bioactive concentrations of apigenin required to obtain the anti-inflammatory pharmacological effects that have been reported in vitro. Apigenin by far the most. Do any ladies here have any experience taking apigenin? I wanted to take it for my insomnia, but I dont want to mess up my hormones. It also was not oral. It is exceptionally broad and powerful anticancer nutrient, right up there with curcumin and EGCG and quercetin. An efficacious dose seems to be between 50 to 200mg of apigenin although this has not been established and camomile flower is by weight approx 0. The primary relaxation effect comes from just drinking the hot tea an tasting a nice flavor (the effects of the flavinoids). nih. Reply reply Posted by u/Efficient-Promise548 - 1 vote and no comments 3 days into taking sublingual NMN powder, TMG and Liposomal Apigenin. Baikal skullcap can be beneficial for sleep for me but it’s not always effective unfortunately Reply reply Hi all, I just wanted to share my not-so-nice experience with apigenin. This is parsley such as you have in your spice rack, pulverized and encapsulated. The supplements may not be needed or have noticeable benefit for an average 24 year old that trains hard and has a good diet. I ordered like maybe 12 of your supplements cause all the ones I’ve tried lately have been insanely effective for me (iso, cognance, saffron, sabroxy and tongkat 10%) all these new products have been a game changer so thank you for all the great work! I have apigenin Somewhere I saw a list of CD-38 inhibitor/regulators that had apigenin as #1, and quercetin as #3, down the list to # 6 was lycopene. Dried parsley can contain about 45 mg apigenin/gram of the herb (%4. I found a post buried on reddit that the dose was too high and 200mg stimulates the brain, although calmly. Thank you for your submission. I mentioned this to my doc who just recently lowered my daily dose of lipitor from 20mg to 10mg and she didn't seem concerned if i took the sleep supplement. apigenin or phosphatidylserine For the last 3 night I've been micro dosing melatonin ( . I sleep amazing and I can tell my REM is vastly improved but I’ve noticed it’s opening “dream portals” very fluidly for me. I wanted to try it because I remembered when I tried it for sleep 50mg didn't really do much except help me relax. gonna leave this one alone though due to the apigenin. How Reddit iOS Reddit Android Reddit Premium About Reddit Advertise Blog Careers Press. I am not sure if it has been causing an increase in irritability, and I just keep waking up multiple times per night. popular-all In my case I take apigenin to prevent cancer recurrence. DHH-B vs Apigenin for anxiety . Which one is the most likely to be causing bloating? I've been having great energy since day one, workouts are feeling great too. It's even better when stacked with polygala. I am determined to quit my medication so the supplement needs to do some heavy lifting. ncbi. Two months ago added Apigenin 200mg in the evenijg for sleep. 5mg of Apigenin, I am thinking of taking about 7g of dried parsley (to reach about 300mg of apigenin). 10, no. “Apigenin reversibly reduced GABA-evoked currents mediated by α1β2γ2 receptors expressed in HEK293 cells. Apigenin is not really effective for sleep for me. I ordered like maybe 12 of your supplements cause all the ones I’ve tried lately have been insanely effective for me (iso, cognance, saffron, sabroxy and tongkat 10%) all these new products have been a game changer so thank you for all the great work! I have apigenin I dont know for Apigenin, but high dose of ferulic acid may be a natural dissociative (1,5-2g) maybe a little more neurotoxic in some condition as its function is of competitive antagonism. Try it for yourself and see. It this study showed that apigenin supplementation in mice prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity. Hi, this post will be short and sweet. This is roughly equivalent to 200 mg of non-lipo apigenin. I’m not taking the others but may try them next as I have trouble sleeping later than early morning. Archived post. Log In / Sign Up; Advertise on Reddit; Shop Collectible Avatars; Tongkat Ali 10% 100mg; Tribulus 500mg; Apigenin 200mg; Cistanche 5%/1% 700mg Wanted to see what your thoughts were on this potential stack. Apigenin + L-Theanine + Magnesium at night has definitely helped me. Baicalin had a really good mood lift, especially when combined with nigella. According to Raal, Ain, et al. I tried it a few nights (not in a row) and each time I was unable to sleep at all for hours. I haven't found anything regarding NO synthase inhibition in the corpus cavernosum. No side effects so far. Dehyrdration reduces nutrient density, so I'm interested in more than apigenin in parsley. Any anecdotal comments elsewhere in the discussion 11K subscribers in the quittingphenibut community. I have received "doonotage" Apigenin today, its 250mg per cap (60caps), recommended serving size on bottle is 2 caps (500mg) I'm just looking for any advice/tips to get the best out of the supplement, I think I have glutamate excitatory issues and low GABA, I don't need it as a sleep aid, can I take it in the morning for anti-anxiety during the day or should I stick to the At the lower studies of the amount of apigenin in dried parsley, you’d have to consuming drastic amounts to reach a common dosage like 200mg of apigenin. Autophagy is intimately associated with the metabolism of lipid droplets (LDs) and is considered to be one of the lipid breakdown pathways. This means that it has no real practical implication for oral use in humans. I have not taken P5P every night and when I only have apigenin and L-theanine I still notice the same increase in REM and deep sleep. Expand user menu Open settings menu. One liposomal variant I use comes from code age, 50 mg per capsule, less than 9 dollars a month. Tall people make more money than short people, according to the article. Huberman saying it is great. It felt like kratoom light with body tingles and positive mood that was remarkably I'm currently taking 600mg parsley capsules once per day, which should contain a decent dose of apigenin. Does anyone have any experience with Apigenin? I heard about it from a random podcast (Huberman Lab) where he mentioned in passing that it was an estrogen blocker. Either way, I love Apigenin. We are not able to validate the content of these discussions. This subreddit is dedicated to men on testosterone replacement with a goal of providing an engaging and cooperative environment to Welcome to r/TRThelp! We are a higher-quality community for men on testosterone. Don’t change anything for a week or so and see if the Apigenin is causing a difference. I will need to look into this more. apigenin-treated mice displayed improvements in memory and learning deficits, the apigenin-treated mice showed restoration of the cortical ERK/cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF) pathway involved in learning and memory typically affected in AD pathology. That’s a great analogy and makes perfect sense. 8h, rapidly metabolized At 3-10mg/kg, no muscle relaxant or sedative effects, but at 30-100mg/kg, sedation was observed Decreased cortisol to 47. My understanding is that the Clomid and Letrozole I took while trying to get pregnant were basically estrogen blockers as well. It has a half life of 91. Has anyone else? If I recall the half life is four days. Has anybody tried both? I'm curious which one works better. i'd still use threonate but just not daily for months. u/QuitVGsForever the issue is, as far as I understand, apigenin is not water soluble (or if it is, it is not very water soluble). It’s probably the l-theanine. I love chamomile but I've tried apigenin at doses from 50-100mg and get these crazy facial/occular spams/blepharospasms from a single dose. Apigenin can upregulate GABA production over time, which helps with sleep. Yes I experienced exactly this. Thanks. I hear people talk about is how apigenin is an OTC LDN alternative. Members Online. I grabbed some dried organic parsley a couple weeks ago to try out (parsley has the highest apigenin content of any dried herb). Better stamina, fuller harder elections. Huberman's sleep stack)doesn't help at all. So if you have fresh parsley and you dry it, the apigenin will not change, but you will go from having 100g fresh parsley to 20g dried parsley. I put it in a smoothie with 150g raw beet, 2g of vanilla bean, 1-2 frozen bananas, and ~15g of Whey protein. Baicalin used to give me a bit of a headache but I haven’t experienced any negative side effects from this product. Last night I forgot to take it, and there was no impact. Anyone has experience in it? Spesifically I want to ask: People who have 150-180ms reaction time did your reaction time improve? Do you think you're perform better in game after taking Apigenin? r/enclomiphene: A place to discuss the usage of enclomiphene as a treatment for secondary hypogonadism and as a PCT. It's been giving me some wild dreams, not bad or good. L-theanine feels like it had the least effect of these 31 votes, 27 comments. Liposomal apigenin I watched a video about sleep and the person recommended Magnesium L-Threonate, Gaba, Apigenin and L-Theanine to supplement for sleep so I bought them and I already take Melatonin but it doesn't help me so I was wondering If I could take all these together. Please consult your doctor for any medical questions or concerns. GABAA partial agonist at the α1 benzo receptor Chamomile is 0. albiflora, kava kava root (must get from well Welcome to r/science!This is a heavily moderated subreddit in order to keep the discussion on science. Try just the apigenin and theanine next time, Come ask questions, post your pictures, whatever you want. I guess I was right. Magnesium alone did not do much for me, but the combo apigenin, P5P, and L-theanine makes me calm, but more importantly, substantially increases the amount of time I spend in REM and deep sleep each night. I also purchased the exact products Andrew mentioned other than Apigenin. I dont know for Apigenin, but high dose of ferulic acid may be a natural dissociative (1,5-2g) maybe a little more neurotoxic in some condition as its function is of competitive antagonism. People keep linking the swiss study, but miss the fact they were injecting the apigenin directly in to the body cavity of the mice 🤣 [] acute exposure through intraperitoneal route to understand the dose dependent effects in Swiss mice. Log In / Sign Up; Advertise on Reddit; Shop Collectible Avatars; 200-300mg of magnesium glycinate 300-400mg of theanine 15mg of apigenin the apigenin is supposed to make neurons to contract and help the brain to turn of thoughts and sleep Apigenin seems to be far more bioavailable in whole food rather than supplementary form, so given the correct dosage you can safely assume it has stronger gabagenic properties. I know the benefits include reduction of CD38, which is a drain on NAD+ levels but with the addition of a liposomal version of this supplement, I'm worried about getting too much, possibly bringing my CD38 levels too low. I think those are size one capsules (400mg typically) so about an eighth apigenin by weight (50mg). If it is not water soluble then it will be a mostly non polar molecule I believe ( I am not well versed enough yet in chemistry) which would also mean it would possibly be better absorbed in the presence of some fatty food on a I've been noticing the same from my TKA + apigenin cycle I've been on. 8-1. szpbpsd eqvcbmj mwonsy xgcwjq buipkr rltb hduv xlqml hhcla bqsohj